VST, VSTi, ASIO. 64 bit only.
This is a not Pro version some extra functions can be locked.

Nuendo 10 is Steinbergs latest and most advanced iteration of their powerful media production digital audio workstation (DAW). Steinberg have listened to user feedback and added loads of new features to improve your workflow and the capabilities of Nuendo.

https://new.steinberg.net/nuendo/